The study of ion specific effects on the aqueous solubility of amino acids and proteins is crucial for the development of many areas of biochemistry and biotechnology. However, direct study of protein-electrolyte interactions is difficult and it is therefore useful to investigate the interaction of model compounds such as amino acids, peptides, and their derivatives. In this research area, the effect of ions with biological relevance on the aqueous solubility of amino acids or derivatives is studied by performing experimental solubility measurements and molecular dynamics simulations. Partial molar volumes are also evaluated, aiming to provide further insights into the interactions of these biomolecules in electrolyte solutions.

Volumetric properties of aqueous solutions of electrolytes and amino acids and their derivatives

Solubility measurements in aqueous electrolyte systems

Simulation results for isoleucine + AlCl3 + water system showing the distances (Å) between selected atoms

Calculated and observed dehydration magnitude (ΔnH) on the amino acids glycine, alanine and serine in the presence of different electrolytes